During 2019, I was working on simulations using CRM designs in several different trials. I found I would frequently get the designs mixed up:
“We are targeting 20% toxicity in this trial, right? No, that was the other trial…we are targeting 33% here…”
Similarly, once or twice, I got to the stage where I wanted to run simulations only to discover we had not specified some important design aspect, like when the trial should stop.